I'm right at 6ft and wish I was 270. I'm ~30lbs north of that. I've owned about 8 motorcycles over my 20 years of riding and the CTX is the most comfortable one I've yet had! I did get the forks redone with RaceTech gear and different oil and I replaced the stock shocks with heavier duty Progressives. Both those mods helped a lot, along with larger ISO grips and a different throttle sleeve/cam to tone down the twitchiness. And a Corbin seat to replace the stock, but I just prefer Corbin seats, I've had them over half of the bikes I've owned.
But even before making any changes the CTX was the most comfortable by a country mile!!
1988 Honda VTX800
2000 Kawasaki Concours
2005 Yamaha FZ600 (Corbin)
1998 Suzuki Bandit 1200 (most uncomfortable)
1999 Honda Aero 1100 (Corbin)
2000 Honda Sabre (Corbin)
2002 Kawasaki Concours (Corbin)
2014 Honda CTX (Corbin)
The CTX does everything I need a bike to and does it well!